How often do I need to use Willo? June 23, 2020 13:48 Updated Follow Twice a day, just like how you would with a regular toothbrush! Related articles I saw a little bit of blood on my mouthpiece after I brushed with Willo, is this normal? Can I use Willo with different members of my household? How often should I replace my mouthpiece? Do I still need to floss after using Willo? Is Willo a waterflosser? Do I still need to go to the dentist for cleaning if I use Willo?